| 14-05 | 19:00 | Peñarol |  | vs |  | Atlético Mineiro | Grp.G |  | |||
| 14-05 | 19:00 | LDU Quito |  | vs |  | Junior Barranquilla | Grp.D |  | |||
| 14-05 | 19:00 | Talleres |  | vs |  | Cobresal | Grp.B |  | |||
| 14-05 | 21:30 | River Plate |  | vs |  | Libertad | Grp.H | | |||
| 14-05 | 23:00 | Millonarios |  | vs |  | Palestino | Grp.E | |
| 14-05 | 19:00 | Racing |  | vs |  | Nacional | Grp.F |  | |||
| 14-05 | 21:00 | Defensa y Justicia |  | vs |  | Independiente Medellín | Grp.A | | |||
| 14-05 | 21:00 | Sportivo Ameliano |  | vs |  | Rayo Zuliano FC | Grp.E | | |||
| 14-05 | 21:30 | Corinthians |  | vs |  | Argentinos Juniors | Grp.F |  | |||
| 14-05 | 23:00 | Nacional Potosí |  | vs |  | Sportivo Trinidense | Grp.D | |
| 13-05 | 20:00 | São Paulo |  | 2-1 |  | Fluminense | R6 |
| 14-05 | 16:00 | Tottenham |  | vs |  | Manchester City | R34 | |
| 14-05 | 14:30 | Osasuna |  | vs |  | Mallorca | R36 |  | |||
| 14-05 | 16:30 | Real Madrid |  | vs |  | Alavés | R36 | | |||
| 14-05 | 17:00 | Girona |  | vs |  | Villarreal | R36 | |
| 14-05 | 19:00 | Avaí |  | vs |  | CRB | R5 |  | |||
| 14-05 | 19:00 | Vila Nova |  | vs |  | Grêmio Novorizontino | R5 |  | |||
| 14-05 | 21:30 | Coritiba |  | vs |  | Guarani | R5 | | |||
| 14-05 | 21:30 | Botafogo-SP |  | vs |  | Chapecoense | R5 | |
| 13-05 | 20:00 | Aparecidense |  | 1-1 |  | São Bernardo | R4 |
| 13-05 | 19:00 | Gimnasia |  | 3-1 |  | Vélez Sarsfield | 1F | ||||
| 13-05 | 21:00 | Unión |  | 1-0 |  | Banfield | 1F |
